asked if anyone knew it's history, so of course (as they knew I would), I went off to "dig".
Finding concrete information back to 1830 is a bit hard so I started with the maps. The earliest map I could find was 1891 and the home is clearly there with the front bay window and porch
|1891 Sanborn Map - Source|
Robert Brown was a pork packer with his warehouse at southeast corner of Sycamore and Court Streets. He must have done well, because by 1870, he was a retired merchant at the age of 58 with the value of his real estate at $8,000 and personal estate at $1,500.
His son, Robert Jr.:
Born in Cincinnati, O., 1836; prepared for his collegiate course under the tutelage of Charles Matthews of Cincinnati; graduated at Yale, 1857; attended Yale Medical School, 1857-58; bookkeeper in a Cincinnati pork-packing house, 1858-66; Assistant Secretary Cincinnati Gaslight and Coke Co., 1866 and later Treasurer and Vice-President of same; Secretary of Yale Observatory 1882 to the present time (1899); founder of the first club of Yale graduates in the United States, and has been actively interested in educational and other useful works.
In 1910, the home has a new owner. It became the home of UC's Sigma Alpha Epsilon fraternity, the first home owned by any fraternity at the University of Cincinnati. Its location was close to the streetcar barn at the top of the Bellevue Incline, earning the E’s the nickname “car barn boys.” (Source)
|Opened by Cincinnati & Clifton Inclined Plane Railroad in 1876, sold in 1880 to Cincinnati Street Railway. Incline connected with Cincinnati Street Railway's McMicken horse car line, which opened in 1881. Cincinnati & Clifton Inclined Plane Railroad also operated horse car line on Ohio Street from top of incline. Incline rebuilt in 1890 to accommodate streetcars. Incline closed down in 1926. - Image Source|
|2210 Ohio Avenue in 1923 - Source|